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Korean J Med > Volume 88(5); 2015 > Article
The Korean Journal of Medicine 2015;88(5): 547-554.
Fracture Risk Assessment와 Framingham Risk Score를 중심으로 한 골절 위험도와 심혈관 질환 위험도와의 상관관계
구인혜1, 이지현1, 김성만2, 강성민1, 김해구1, 김동규1, 최준설1, 박석기1
1메리놀병원 류마티스내과
2메리놀병원 심장내과
Identification of a Link between Framingham Risk Score and Fracture Risk Assessment Tool
In Hye Ku1, Ji Hyun Lee1, Seong Man Kim2, Sung Min Kang1, Hae Koo Kim1, Dong Kyu Kim1, Joon Sul Choi1, Suk Ki Park1
1Divisions of Rheumatology, Department of Internal Medicine, Maryknoll Medical Center, Busan, Korea
2Divisions of Cardiology, Department of Internal Medicine, Maryknoll Medical Center, Busan, Korea
Corresponding Author: Ji Hyun Lee ,Tel: +82-51-461-2475, Fax: +82-51-441-6950, Email: ete@lycos.co.kr
Received: July 5, 2014;   Revised: October 24, 2014;   Accepted: January 15, 2015.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Although trials have suggested an association between osteoporosis and cardiovascular disease (CVD), the relationship between fracture risk and cardiovascular disease is not well defined. Here, we examined whether subjects with a higher risk of fracture also share an increased likelihood of developing CVD.
This study included 477 subjects; patients with a history of diabetes, chronic hepatopathy, nephritic syndrome, or any cardiovascular diseases were excluded. We used dual energy X-ray absorptiometry to assess the bone mineral density (BMD) of the lumbar spine and femur, and calculated fracture risk based on the Fracture Risk Assessment (FRAX) score. The Framingham risk score (FRS) was used to estimate cardiovascular risk.
Of the 477 subjects, 222 had osteopenia and 150 had osteoporosis; the remaining 105 had a normal BMD. In men, no significant differences were observed in systolic blood pressure (SBP), diastolic blood pressure, low-density lipoprotein, high-density lipoprotein (HDL), and triglyceride (TG) between groups. Men with osteoporosis were generally older, and had significantly higher total cholesterol (TC). In women, age and FRS were significantly higher in the osteoporosis group. In the multivariate analysis, age, SBP, TC, HDL, TG, and FRAX were all significantly associated with FRS.
These data suggest that patients with a higher risk of fracture are also at greater risk of developing CVD, indicating a possible mechanistic link between CVD and osteoporosis.
Keywords: Osteoporosis; Cardiovascular diseases; Fracture risk; Risk assessment
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