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Korean J Med > Volume 87(6); 2014 > Article
The Korean Journal of Medicine 2014;87(6): 698-704.
ABO 혈액형 부적합 신장이식 환자에서 혈연 간 신장이식과 비혈연 간 신장이식의 성적 비교
박우영1,3, 한승엽1,3, 황은아1,3, 박성배1,3, 박의준2,3, 김형태2,3, 조원현2,3
1계명대학교 의과대학 내과학교실
2계명대학교 의과대학 외과학교실
3계명대학교 신장연구소
Clinical Outcomes between Living Related and Living Unrelated Kidney Transplantation in ABO-Incompatible Kidney Transplant Recipients
Wooyeong Park1,3, Seungyeup Han1,3, Eunah Hwang1,3, Sungbae Park1,3, Uijun Park2,3, Hyungtae Kim2,3, Wonhyun Cho2,3
1Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea
2Department of Surgery, Keimyung University School of Medicine, Daegu, Korea
3Keimyung Kidney Institute, Daegu, Korea
Corresponding Author: Seungyeup Han ,Tel: +82-53-250-7399, Fax: +82-53-253-7976, Email: hansy@dsmc.or.kr
Received: April 13, 2014;   Revised: May 1, 2014;   Accepted: May 15, 2014.
ABSTRACT
Background/Aims:
Kidney transplantation (KT) is the best treatment for end-stage renal disease patients. Although previous studies have demonstrated that the clinical outcome following living related (LR) KT is better than that following unrelated (LUR) KT in ABO-compatible KT recipients, recent studies showed no differences in clinical outcomes between the two treatments. In this study, we compared the clinical outcomes of LR and LUR KT in ABO-incompatible KT recipients.
Methods:
From January 2011 to August 2013, 19 cases of ABO-incompatible KT were analyzed retrospectively. Eight kidneys (7 cases of parent-offspring and 1 case of siblings, Group 1) were donated from living-related donors and 11 (all spousal donors, Group 2) from living-unrelated donors. We investigated patient survival, graft survival, acute rejection, graft function, and complications.
Results:
On Kaplan-Meier analysis, patient and graft survival during follow-up were 87.5% and 87.5% in Group 1; both were 100% in Group 2. Acute rejection, graft function, and medical and surgical complications were not significantly different between the two groups.
Conclusions:
The short-term clinical outcomes between LR and LUR KT in ABO-incompatible KT recipients were equivalent. Most domestic cases of LUR KT are from spousal donors and the spousal donor will be a major donor in ABO-incompatible KT patients.
Keywords: Kidney transplantation; Living-unrelated; ABO-incompatible
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