| A Case of Secondary Primary Malignancy after Lenalidomide Therapy for Multiple Myeloma |
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Hye Jung Lee, Eun Seok Kim, Ho Jin Lee, Sang Hyeon Kang, In Chul Park, Ji Hyun Lee, Sung-Hyun Kim |
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Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea |
| 다발성 골수종에서 Lenalidomide 치료 후 발생한 이차성 원발 종양 1예 |
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이혜정, 김은석, 이호진, 강상현, 박인철, 이지현, 김성현 |
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동아대학교 의과대학 내과학교실 |
Correspondence:
Sung-Hyun Kim, Tel: +82-51-240-2608, Fax: +82-51-246-5044, Email: kshmoon@dau.ac.kr
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Received: 25 July 2013 • Revised: 6 August 2013 • Accepted: 13 August 2013 |
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| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits
unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Abstract |
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Lenalidomide, an orally administered immune-modulating drug, has several mechanisms of action against multiple myeloma (MM). However, the mechanisms of action of immune-modulating drugs are not understood completely. Lenalidomide maintenance therapy prolongs the time to progression and increases the overall survival in patients with MM. However, secondary primary malignancy (SPM) has been noted as a serious adverse event in patients with MM treated with lenalidomide. Lenalidomide treatment is not covered by insurance. Consequently, physicians have little experience with the adverse events of lenalidomide treatment in patients with MM. Here, we describe a case of breast cancer after lenalidomide treatment for MM. To our knowledge, this is the first report of a lenalidomide-associated SPM in Korea. The risk factors associated with lenalidomide-associated SPM should be considered carefully when implementing chemotherapy regimens in patients with MM. (Korean J Med 2014;86:353-356) |
| Key Words:
Multiple myeloma; Lenalidomide; Breast cancer; Secondary primary malignancy |
| 주제어:
다발성 골수종; 이차성 원발종양 |
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