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Case Report
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Korean J Med. 2015;88(6):732-736. Published online June 1, 2015.
DOI: https://doi.org/10.3904/kjm.2015.88.6.732
- 아스피린과민성 환자에서 메페리딘에 의해 유발된 알레르기 반응 1예
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서민교1, 노태훈1, 정희정1, 김용완2, 김용한3, 정재원4, 박찬선1
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1인제대학교 의과대학 해운대백병원 내과
2인제대학교 의과대학 해운대백병원 이비인후과
3인제대학교 의과대학 해운대백병원 마취통증의학과
4인제대학교 일산백병원 내과
- Allergic Reaction to Meperidine in a Patient with Aspirin Idiosyncrasy
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Min Gyo Seo1, Tae Hoon No1, Heui Jeong Jeong1, Young Wan Kim2, Young Han Kim3, Jae Won Jung4, Chan Sun Park1
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1Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
2Department of Otorhinolaryngology-Head and Neck Surgery, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
3Department of 1Internal Medicine, Anesthesiology and Pain Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
4Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea
- Corresponding author: Chan Sun Park ,Tel: +82-51-797-2211, Fax: +82-51-797-2212, Email: chansun@paik.ac.kr
- Received: January 28, 2014; Revised: August 19, 2014 Accepted: October 29, 2014.
- 본 증례는 아스피린/비스테로이드성 진통소염제 과민성과 만성 두드러기 환자에서 대체약물로 비교적 안전하게 사용되는 아편유사체진통제인 메페리딘에 대한 IgE 매개 급성 전신 두드러기 증례로 국내에서는 첫 번째 보고라는 점에서 의의가 있다. 임상에서 흔히 사용하는 약물이기 때문에 투여 후 주의 깊은 관찰이 필요하며 즉시형 과민반응이 의심되는 경우에는 병인기전의 확인이 필요할 것으로 생각된다.
߽ɾ :알레르기; 아스피린; 메페리딘; 두드러기
- Abstract
- Although narcotic analgesics are potent releasers of histamine, IgE-mediated allergic reactions to these drugs are rare. Here we report the case of a 56-year-old male who suffered from chronic urticarial and analgesics-induced skin rashes. He visited our allergy clinic to determine alternative analgesics before undergoing surgery. A drug provocation test showed a positive reaction to aspirin, but negative reactions to acetaminophen and celecoxib. Despite careful attention to his drug regimen, during surgery he developed generalized urticaria and flushing. Skin tests of allergy to latex, lidocaine, propofol, rocuronium, flomoxef, meperidine, palonosetron, pyridostigmine, and fentanyl yielded negative results, except for the prick and intradermal tests with meperidine. Thus, this patient had both an aspirin/non-steroidal anti-inflammatory drugs idiosyncrasy and an IgE-mediated hypersensitivity to meperidine.
Keywords :Hypersensitivity, Aspirin, Meperidine, Urticaria
