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Case Report
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Korean J Med. 2015;88(6):715-718. Published online June 1, 2015.
DOI: https://doi.org/10.3904/kjm.2015.88.6.715
- 메토트렉세이트 사용 중 발생한 간을 침범한 광범위큰B세포림프종 1예
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천재영1, 최희승2, 조세희1, 이서희1, 조미옥1, 이민영1, 김유리1
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1연세대학교 의과대학 강남세브란스병원 내과
2연세대학교 의과대학 강남세브란스병원 병리과
- A Case of Diffuse Large B-cell Lymphoma with Liver Involvement in a 67-Year-Old Woman Given Methotrexate for Rheumatoid Arthritis
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Jae Young Cheon1, Hee Seung Choi2, Se Hee Jo1, Seohui Lee1, Mi Ok Cho1, Min-Young Lee1, Yu Ri Kim1
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1Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
2Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- Corresponding author: Yu Ri Kim ,Tel: +82-2-2019-3503, Fax: +82-2-3463-3882, Email: glassy@yuhs.ac
- Received: June 26, 2014; Revised: August 25, 2014 Accepted: September 25, 2014.
- 장기간 면역억제제를 사용하는 경우 감염 등의 합병증뿐만 아니 장기간의 면역억제로 인한 림프종의 발생위험도 고려해야 한다. 저자들은 류마티스관절염으로 MTX를 15년간 복용한 병력이 있는 환자에서 간과 비장을 침범한 광범위큰B세포림프종이 발생한 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
߽ɾ :메토트렉세이트; 광범위큰B세포림프종; 류마티스관절염
- Abstract
- Prolonged inflammation or immunosuppression may cause lymphoproliferative disorders (LPD). Rheumatoid arthritis (RA) itself causes LPD. The immunosuppressive drug methotrexate (MTX) is used widely to treat RA, and is also related to the development of lymphoma. Although the detailed pathogenesis and association are still controversial, care is needed when managing patients with RA treated with MTX. Many reports indicate that discontinuing MTX can induce the regression of LPD. Here, we describe a case of diffuse large B-cell lymphoma that presented with liver involvement in a 67-year-old woman who had used MTX for RA for 15 years.
Keywords :Methotrexate, Diffuse large B-cell lymphoma, Rheumatoid arthritis
