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Case Report
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Korean J Med. 2014;87(1):96-100. Published online July 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.87.1.96
- 헤노흐-쇤라인 자색반과 동반된 IgG4 연관 요세관간질 신염
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양 현, 최수경, 김보경, 유지연, 고은실, 장윤식, 정성진
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가톨릭대학교 의과대학 내과학교실
- IgG4-Related Tubulointerstitial Nephritis Accompanied by
Henoch-Schönlein Purpura
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Hyun Yang, Soo Kyoung Choi, Bokyoung Kim, Ji Yeon Yoo, Eun Sil Koh, Yoon Sik Chang, Sungjin Chung
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Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea
- Corresponding author: Sungjin Chung ,Tel: +82-2-3779-2413, Fax: +82-2-780-3132, Email: sungjin.chung@outlook.com
- Received: September 13, 2013; Revised: October 23, 2013 Accepted: November 7, 2013.
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- Abstract
- Tubulointerstitial nephritis is one of the common manifestations of immunoglobulin G (IgG)4-related disease; however, among
all cases of tubulointerstitial nephritis undergoing renal biopsies, IgG4-related tubulointerstitial nephritis seems to be relatively rare
because of its trivial urinary findings. A previously healthy 54-year-old man was referred to our clinic with a 4-week history of
lower leg purpura and renal dysfunction. A kidney biopsy was planned because of bilateral renomegaly, by imaging studies, and
elevated serum creatinine levels. Pathological findings in the kidney showed prominent infiltration of IgG4-postive plasma cells in
the tubulointerstitium, but not the glumeruli. A skin biopsy revealed leukocytoclastic vasculitis, accompanied by deposition of IgA
and C3 in the vascular wall, indicating Henoch-Schönlein purpura (HSP). Although cases of combined IgG4-related disease and
microvasculitis, including HSP, are extremely rare, the possibility of an association between two diseases deserves attention.
Keywords :Immunoglobulin G4, Nephritis, Interstitial, Henoch-Schönlein purpura
