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Original Article
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Korean J Med. 2010;78(2):262-272.
- 자각 증상과 심장비대 없이 심장 침범된 Churg-Strauss 증후군
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김수아, 안희경, 이수진, 이준호, 정윤진, 이병재, 최동철
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- A case of cardiac involvement in Churg-Strauss syndrome presenting without cardiomegaly in an asymptomatic patient
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Su-A Kim, Hee Kyung Ahn, Su Jin Lee, Jun Ho Yi, Yun-Jin Jeung, Byeoung Jae Lee, Dong-Chull Choi
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- Abstract
- We report a case of Churg-Strauss syndrome with cardiac involvement presenting without cardiomegaly or cardiopulmonary symptoms. A 47-year-old woman was referred to our institution for myalgia, peripheral numbness, and eosinophilia. She had been diagnosed with bronchial asthma and allergic rhinitis four years ago. The patient exhibited eosinophilia (71%) and elevated cardiac enzymes (cTnI, 2.977 ng/mL). Cardiomegaly was not observed on chest radiography, but nonspecific ST segment changes were observed on electrocardiography. A transthoracic echocardiography revealed a dilated left ventricular cavity, a decreased left ventricle (42%), and diastolic dysfunction. Contrast-enhanced cardiac magnetic resonance imaging revealed delayed hyperenhancement 10 minutes after injecting gadolinium. An endomyocardial biopsy showed eosinophilic myocarditis associated with vasculitis. The patient was diagnosed with Churg-Strauss syndrome and received combination therapy with steroid and cyclophosphamide. After the second treatment cycle, the blood eosinophilia disappeared and the vasculitis and infiltration of eosinophils into the endomyocardial tissue had completely resolved. (Korean J Med 78:266-272, 2010)
Keywords :Churg-Strauss syndrome, Endomyocardial biopsy, Eosinophilic myocarditis
