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Original Article
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Korean J Med. 2009;77(5):1347-1351.
- 종합비타민 정주투여 후 발생한 과민반응 4예
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이인정·김소연·안정선·손경민·이서희·한보람·강혜련, , , , , ,
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- Allergic reactions to a multivitamin
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In-Joung Lee, So-Yeon Kim, Jung-Sun An, Kyeong-Min Son, Seo-Hee Lee, Bo-Ram Han, Hye-Ryun Kang
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- Abstract
- Parenteral vitamin supplements are frequently used in normal subjects and patients with vitamin deficiencies. The incidence rate
of an allergic reaction to a multivitamin is less than 0.1%. We recently experienced four young patients who showed severe immediate
allergic reactions after administration of an intravenous multivitamin. A 21-year-old male who was admitted for diarrhea suddenly
felt chest tightness, shortness of breath, high fever, and generalized pruritus with facial flushing within a few minutes after beginning
a dextrose fluid drip mixed with a multivitamin solution. The patient’s symptoms subsided in 20 minutes after fluid administration
stopped. The patient showed positive response to intradermal tests using a multivitamin, vitamin B-complex, and thiamine
solution. We also observed similar responses to a multivitamin in three other young patients, and all of them showed positive reactions
on a skin test using a multivitamin solution. Including the above-described patients, we have experienced 17 cases of potential
multivitamin-induced hypersensitivity reactions over the past year. Based on our experience, multivitamin-related allergic reactions
are not rare. Therefore, more attention to vitamins as a cause of severe allergic adverse reaction is required. (Korean J Med
77:S1347-S1351, 2009)
Keywords :Hypersensitivity, Vitamin
