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Original Article
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Korean J Med. 2009;76(1):238-242.
- Cefotiam 접촉에 의한 아나필락시스 1예
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이기홍, 최인선, 이우진, 강승지, 정혜경
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- A case of cefotiam-contact anaphylaxis
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Ki Hong Lee, Inseon S. Choi, Woo Jin Lee, Seung Ji Kang, Hye Kyeong Jeong
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- Abstract
- Anaphylaxis caused by β-lactam antibiotics usually develops following the systemic administration of the drug, although it can
also occur with trivial contact of the drug on the skin in extraordinarily sensitive individuals. Cefotiam is a second-generation cephalosporin
developed in Japan, and cefotiam-induced contact urticaria and systemic symptoms (contact urticaria syndrome) have
been reported in several nurses from Japan and Korea. Considering the serious nature of the systemic manifestations, such as hypotension,
contact anaphylaxis is a more appropriate name for severe forms of the disease than contact urticaria syndrome. No previous
study has reported a case involving contact urticaria syndrome to multiple drugs. We describe a case of cefotiam-induced contact
anaphylactic shock combined with cefoperazone/sulbactam-induced contact urticaria syndrome in a 24-year-old nurse. She exhibited
positive skin prick test responses to both cefotiam and cefoperazone/sulbactam. (Korean J Med 76:S238-S242, 2009)
Keywords :Anaphylaxis, Cefoperazone, Cefotiam, Contact urticaria syndrome, Sulbactam
