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Original Article
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Korean J Med. 2009;76(4):459-466.
- 최근 5년간 신증후군 출혈열의 임상양상:백신 도입 이전과 비교
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이남석, 김효열, 채명훈, 김은미, 박소연, 한상훈, 권오건, 어 영
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- The influence of vaccination on the clinical features of hemorrhagic fever with renal syndrome in the last 5 years
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Namseok Lee, Hyo Youl Kim, Myeong Hun Chae, Eunmi Kim, So Yeon Park, Sang Hoon Han, Ohgun Kwon, Young Uh
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- Abstract
- Background/Aims: Hemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus is an endemic febrile disease in
Korea. Although inactivated Hantaan virus vaccine has been introduced, the effect of vaccination is not clear. We evaluated the effect
of vaccination on the incidence rate and clinical features of HFRS based on our clinical experience.
Methods: Group I consisted of the patients with confirmed HFRS from a total of 131 patients who were seropositive for Hantaan
virus at one tertiary teaching hospital from January 2002 to December 2006. Group II contained 100 patients treated as HFRS at the
same hospital from January 1986 to December 1990, before the introduction of the vaccine. Then, we compared the clinical features
of the two groups. We confirmed whether the patients had been vaccinated by reviewing their medical records and from telephone
interviews.
Results: Only 16 (12.2%) of the 131 patients who were seropositive for Hantaan virus were confirmed to have overt HFRS during
the most recent 5 years. The incidence of overt HFRS was significantly lower in vaccinees (5%, 3 of 56) than in non-vaccinees
(20%, 10 of 50) (p=0.025). The prevalence of renal failure (62.5 vs. 95%, p<0.001) and oliguria (6.25 vs. 46%, p=0.002) was significantly
lower in group I than in group II. Three patients were treated with dialysis and none died in group I, versus 17 and 8, respectively,
in group II.
Conclusions: It appears that Hantaan virus vaccine has helped to reduce the amount of serious illness and the occurrence of
HFRS. (Korean J Med 76:459-466, 2009)
Keywords :Hemorrhagic Fever with Renal Syndrome, Vaccination, Hantaan virus
