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Original Article
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Korean J Med. 2008;75(3):858-861.
- 증례 : 갈색세포종에서 18FDG의 전신 갈색지방조직 섭취를 보인 증례 1예
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홍수정.김경민.이유미, .윤미진.이종두.이은직, .임승길, , , ,
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- Diffuse 18F-fluoro-2-deoxy-D-glucose uptake of brown adipose tissue in pheochromocytoma due to increased sympathetic nervous system activity
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Soo Jung Hong, Kyoung Min Kim, Yumie Rhee, Mijin Yoon, Jong Doo Lee, Eun Jig Lee, Sung Kil Lim
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- Abstract
- A pheochromocytoma is a tumor of chromaffin cells that originates from either the adrenal medulla or extra-adrenal sympathetic tissues. The diagnosis of pheochromocytoma is based on elevated concentrations of plasma and urinary catecholamines or their metabolites. In most patients, the anatomic localization of the tumor is determined with computed tomography or magnetic resonance imaging. However, metaiodobenzylguanidine-scintigraphy or positron emission tomography (PET) can also easily identify the foci of neuroendocrine tumors. We diagnosed a patient with pheochromocytoma and high urinary norepinephrine levels, whose PET images revealed diffuse 18F-fluoro-2-deoxy-D-glucose (18FDG) accumulation in the shoulder, lower neck, and perivertebral area. The regions of 18FDG uptake corresponded to the location of human brown adipose tissue (BAT), which is minimally active in adults. It is thought that excessive sympathetic stimulation by high circulating catecholamine concentrations augmented the metabolic activity and tracer uptake in the BAT. This uptake in the BAT was normalized after surgical resection. (Korean J Med 75:S858-S861, 2008)
Keywords :Pheochromocytoma, Brown adipose tissue, Catecholamines, Positron-emission tomography
