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Original Article
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Korean J Med. 2008;74(2):198-202.
- 증례 : 게피티닙 치료로 호전된 폐선암의 전이성 수막암종증 1예
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유성근 . 박원종 . 박찬서 . 진현정 . 신경철 . 정진홍 . 이관호, , , , , ,
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- A case of leptomeningeal metastasis from adenocarcinoma of the lung improved by treatment with Gefitinib
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Sung Ken Yu, Won Jong Park, Chan Soh Park, Hyun Jung Chin, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee
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경희대학교 의과대학 순환기내과학교실
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- Abstract
- Leptomeningeal metastasis occurs in approximately 1% of patients with non-small cell lung cancer and this is an extremely serious complication. Without treatment, the median survival of patients is 4~6 weeks. The treatment options currently available are limited and achieve only modest results. Gefitinib was recently approved for the teatment of advanced/refractory non-small cell lung cancer. In addition, there have been case reports showing activity of gefitinib against brain metastasis in non-small cell lung cancer patients. However, there is limited data on the ability of gefitinib to cross the blood-brain barrier. We report the case of a patient with leptomeningeal metastasis from adenocarcinoma of the lung that had a dramatic response to gefitinib treatment.
Keywords :Leptomeningeal metastasis, Non-small cell lung cancer, Gefitinib
