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Original Article
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Korean J Med. 2007;73(3):1039-1044.
- 증례 : 성인에서 림프절 만을 침범한 랑게르 한스 조직구증 1예
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이윤정&#;김수연&#;홍숙희&#;우인숙&#;변재호, , , ,
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- A case of isolated multiple lymph node involvement of Langerhans cell histiocytosis in an adult
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Yune Jeong Lee, Su Yoen Kim, Sook Hee Hong, In Sook Woo, Jae-Ho Byun
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전남대학교병원 심장센터, 간호부, 전남대학교 심혈관계 특성화 사업단
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- Abstract
- Langerhans cell histiocystosis or Histiocytosis X is characterized by the proliferation of Langerhans cells. The clinical
manifestations vary from localized solitary lesion to multifocal unisystem disease (Hand-Schuller-Christian disease) or
multifocal, multi-systemic disease (Letterer-Siwe disease). In unisystem disease, it usually involves bone or lung, but it
is relatively unusual to involve the skin, pituitary/thalamus or lymph nodes. The clinical course also varies from
spontaneous regression to a life-threatening event. A solitary bone lesion can be managed by surgical resection, local
radiation therapy or both. However multi-systemic lesion, and especially extra skeletal disease, may require systemic
chemotherapy, which is most commonly a vinblastine based regimen.
We report here on a case of Langerhans cell histiocytosis in an older-age patient, and the patient presented with only
multiple lymph node involvement. He responded well to combination chemotherapy.(Korean J Med 73:S1039-S1044, 2007)
Keywords :Langerhans cell histiocytosis, Lymph node, Chemotherapy
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