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Original Article
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Korean J Med. 2007;73(3):857-865.
- 증례 : 비 아칼라지아성 식도 운동 질환에서 내시경적 보툴리눔 독소 주입 치험 3예
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김명현&#;김민수&#;김영균&#;김희선&#;박효진, , , ,
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- Endoscopic botulinum toxin injection in three cases with non-achalasic oesophageal motility disorders
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Myung Hyun Kim, Min Soo Kim, Young Kyoon Kim, Hee Sun Kim, Hyojin Park
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전남대학교병원 심장센터, 간호부, 전남대학교 심혈관계 특성화 사업단
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- Abstract
- Oesophageal motility disorders are common clinical problems. Various gastrointestinal tract motility disorders such as
achalasia, diabetic gastroparesis, Oddi sphincter dysfunction and chronic anal fissure have been treated by endoscopic
botulinum toxin injection. Recently, we successfully treated three cases of non-achalasic oesophageal motility disorder
with botulinum toxin injection. One patient had diffuse oesophageal spasm and the two others had hypertensive lower
oesophageal sphincter. All three underwent upper endoscopy during which 100 units of botulinum toxin were injected into
the causative lesion. Repeated oesophageal manometry and evaluation with the structured symptom score questionnaire
(Eckardt score, dysphagia symptom score) were carried out before and after the procedure. We evaluated improvement
by repeating studies and the symptom score questionnaire in three patients. There were no visible complications noted.
We conclude that botulinum toxin injection for non-achalasic oesophageal motility disorders may be a promising
therapeutic option.(Korean J Med 73:S857-S865, 2007)
Keywords :Botulinum toxin injection, Diffuse oesophageal spasm, Hypertensive lower oesophageal sphincter, Non-achalasic oesophagea
