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Original Article
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Korean J Med. 2007;73(2):131-141.
- 원저 : 복막투석 환자에서 시간의 경과에 따른 혈액과 투석액의 렙틴의 변화에 대한 연구
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박종원, 도준영
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- Changes of the serum and dialysate leptin in continuous ambulatory peritoneal dialysis patients with time
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Jong-Won Park, Jun Young Do
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한림대학교 의과대학 내과학교실 강동성심병원 심혈관센터
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- Abstract
- Background : The aim of this study was to investigate the changes of fat mass and the serum and dialysate leptin among CAPD patients with time.
Methods : 52 patients were enrolled. The S- and D-leptin and BIA were measured at the 2nd week and the 12th month after initiation of PD.
Results : 1) There were significant increases in fat mass, but significant decreases in the ECF% and lean body mass at the 12th month after initiation of PD (p<0.01, respectively).
2) There were significant increases in the S-leptin, D-leptin and D-VEGF at the 12th month after initiation of PD (p<0.00, respectively).
3) There were significant increases in the fat mass, S-leptin and D-leptin at the 12th month after initiation of PD in both males and females, according to the gender (p<0.05, respectively). According to the etiology, there were significant increases in the fat mass, S-leptin and D-leptin in the diabetic patients (p<0.001, respectively).
4) Factors associated with the changes of fat mass during the first 1 year were nPCR, D/P 4hr Cr, glucose absorption via the peritoneal cavity and the duration of dialysis (p<0.05, respectively).
5) Factors associated with the changes of S-leptin during the first 1 year were diabetes, % fat mass and the hs-CRP (p=0.05, respectively). Factors associated with the changes of D-leptin were D/P4 Cr, % fat mass and the S-leptin (p<0.05, respectively)
6) Factors associated with the changes of D/S leptin during the first 1 year were D/P 4hr Cr, % fat mass, hs-CRP, the duration of dialysis and the D-VEGF (p<0.05, respectively)
7) There were significant correlations between delta D-VEGF and delta D/S leptin during the 1st year.
Conclusions : Increased leptin levels of serum and dialysate might be associated with the fat mass in PD patients
with time.(Korean J Med 73:131-141, 2007)
Keywords :Peritoneal dialysis, Continuous amburatory, Intra abdominal fat, Leptin
