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Review
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Korean J Med. 2006;71(1):266-266.
- Does Ulcerative Proctitis Progress to Extensive Colitis Depend on Treatment or not?
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., , , , ,
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- Does Ulcerative Proctitis Progress to Extensive Colitis Depend on Treatment or not?
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, , , , ,
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1Department of Internal Medicine, Hanyang University College of Medicine, Seoul; 2Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
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- Abstract
- Background : The incidence and prevalence rates of Ulcerative colitis (UC) in Korea are still low compared with those of
Western countries, but have been increasing rapidly during the past decades. Clinical characteristics of UC in Asian population
are not well recognized. Therefore we investigated the clinical course of UC, especially limited UC (proctitis, proctosigmoiditis)
in Korea. Methods : We retrospectively analyzed 211 UC patients first diagnosed and long term follow up colonoscopic examined
at Yeungnam University Medical Center between 1989 and 2006. Initial diagnosis was made by clinical, endoscopic and
pathologic finding and divided group by extent of disease. We reviewed extension of lesion by follow up endoscopic finding and
symptom depend on treatment. Results : The male to female ratio was 1:1.1 and the median age at diagnosis was 46.0 years
(range, 17-83 years). At diagnosis, proctitis was noted in 70 patients (33.2%), proctosigmoiditis in 40 (19%), left-sided colitis in
22 (10.4%), extensive colitis in 79 (37.4%). Further extension in the colon was most frequently observed in patients with proctitis
(22.8%). In patients with proctosigmoiditis, further extension was observed in 17.5% of the patients. In the patients initially
diagnosed with proctitis, 28.6% of the patients were not taking any kind of medication for UC and 54 patients (77%, treatment
group 34 patients, untreatment group 20) had not progressed during the observation period (56 months, range 2-193 months).
In the patients initially diagnosed with proctosigmoiditis, 12.5% of the patients were not taking any kind of medication for UC
and 33 patients (83.5%, treatment group 28 patients, untreatment group 5) had not progressed during the observation period. The
maximal extent of the disease was not affected by treatment (P = 0.99). Conclusions : The initial extent of the disease in
Korean UC patients was similar to that found in other Western studies. In the present study, most of limited ulcerative colitis
(77-82%) did not progress to extensive colitis regardless of treatments, but large scale multi-center analysis was needed.
Keywords :
