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Review
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Korean J Med. 2006;71(1):227-227.
- Gastrointestinal stromal tumors of the stomach: endosonographic differentiation in relation to histologic risk
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Hyun Chaol Lee, Seong Woo Jeon, Young Dae Park, Yun Jin Chung, Chang Min Cho, Won Young Tak, Young Oh Kweon, Sung Kook Kim, Yong Hwan Choi
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- Gastrointestinal stromal tumors of the stomach: endosonographic differentiation in relation to histologic risk
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중앙대학교 병원 내과학교실, 비뇨기과 교실, Cell genomics
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- Abstract
- Background and Aim : The aim of this study was to determine the endosonographic characteristics of gastrointestinal stromal
tumors (GISTs) of the stomach according to histologic risk classification. Methods : Twenty-four cases of histologically proven
c-kit positive GISTs were divided into three groups according to histologic risk: low risk (n=14), intermediate risk (n=7), and
high risk (n=3). The endoscopic ultrasonography (EUS) features recorded were: size, ulceration, regularity of marginal border,
lobulation, shape of tumor, marginal halo, homogeneity, internal echogenic or cystic foci, as well as the presence of exophytic
development. Results : Significant differences were seen in size between the groups studied (p=0.026). All tumors in the high
risk group had mucosal ulceration, which was more commonly seen in the intermediate risk group compared to the low risk
group (p=0.014). All tumors in the high risk group had irregular borders, but only 3 cases out of 11 in the low risk group had
irregular borders (p=0.039). Thirteen cases in the low risk group and 5 cases in the intermediate risk group had an oval or round
shape; however, only 1 case in the high risk group (p=0.043). The optimal size value for prediction of intermediate and high risk
group was 30mm. The sensitivity and specificity with this value were 80% and 79%, respectively. Conclusions : Large,
especially larger than 30mm, GISTs of the stomach with irregular borders, mucosal ulceration and a non-oval shape on EUS
suggest higher risk GISTs of the stomach. These criteria may aid in clinical management of GISTs of the stomach.
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