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Review
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Korean J Med. 2006;71(1):216-216.
- Detection rate of Helicobacter pylori against a Background of Atrophic gastritis and/or Intestinal metaplasia
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- Detection rate of Helicobacter pylori against a Background of Atrophic gastritis and/or Intestinal metaplasia
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1Department of Internal Medicine, Hanyang University College of Medicine, Seoul; 2Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
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- Abstract
- Backgound : To evaluate the detection rate of the CLOtest, Giemsa stain and culture for the diagnosis of Helicobacter pylori
(H. pylori) organisms in patients with or without atrophic gastritis (AG) and/or intestinal metaplasia (IM).
Methods
: We used either the CLOtest, Giemsa staining or culture to determine the presence of H. pylori in 430 subjects who
were documented to be infected with H. pylori from Sep. 2003 to Jun. 2006. The detection rates of the methods were evaluated
according to the presence of AG and IM in antrum and body, which were classified using the updated Sydney system
classification.
Results
: Positivity by the CLOtest markedly reduced depending on the degree of AG and IM in both antrum and body (p <
0.05), and the positivity of Giemsa staining was markedly reduced as the degree of IM increased (p < 0.01), but was not affected
by the degree of AG (p = 0.08) in antrum or body. When the results of these tests were evaluated in terms of combinations
of AG and IM, the positivity of CLOtest was found to be lower in AG with IM than in AG without IM, (50.0% vs. 80.0% in
antrum, 47.5% vs. 78.0% in body, respectively, p < 0.01). In addition, the positivity of Giemsa stain was less frequent in AG
with IM than in AG without IM in antrum (65.1% vs. 100% respectively, p < 0.01). However, the positivity of Giemsa stain in
the body showed no statistical difference between AG without IM and AG with IM (97.6% vs. 91.7% respectively).
Conclusion
: Invasive H. pylori tests, especially the CLOtest, had a lower detection rate for H. pylori in the presence of mucosal
atrophy and intestinal metaplasia, and this became more prominent in the presence of higher levels of intestinal metaplasia and
atrophic gastritis.
Keywords :Helicobacter pylori, Atrophic gastritis, Intestinal metaplasia
