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Review
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Korean J Med. 2006;71(1):196-196.
- 한국인에서 류마티스 관절염의 치료적 관해
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이유현&#;강은숙&#;이지수
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1Department of Internal Medicine, Hanyang University College of Medicine, Seoul; 2Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
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- Abstract
- Objective : To define the remission based on American College of Rheumatology (ACR) preliminary criteria in Korean patients
with rheumatoid arthritis (RA). Methods : Random samples of 109 patients with RA in Ewha medical center were selected.
Remission was defined by ACR preliminary criteria. Data were obtained from cross-section of the 4 follow up years (May 2001
to May 2006). Data on initial tender joint count (TJC) and swollen joint count (SJC), treatment, disease duration, initial ESR,
CRP, and rheumatoid factor (RF) were performed on the last clinical visit. Results : Eighty three patients (76.1%) were in ACR
defined remission. Mean¡¾SD remission duration was 16.8¡¾15.9 years. The characteristics of patients in remission group
compared to the non-remission group were shorter disease duration (34.3¡¾68.7 vs. 70.3¡¾71.7 months, p=0.023), early disease less
than 2 years (73.5% vs. 34.6%, p=0.000). Moreover, they had lower initial ESR and RF. The proportion of patients treated with
DMARDs combination therapy in the remission group was 89.2%, whereas 80.8% in the non-remission group. RF titer was
decreased in remission group after DMARDs treatment (p=0.011). Seronegative conversion of RF was frequently found in the
remission group than non-remission group (15.5% vs. 5.3%), but did not affect the achievement of remission. In the
non-remission group, pain was the most persistently non-satisfying clinical variable of the ACR preliminary criteria. Conclusion
: Clinical remissions in patients with RA were achieved in 76.1%, and in patients at early stage of disease were done in higher
rate by aggressive treatment. ACR criteria was useful in evaluating remission status in RA.
Keywords :
