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Original Article
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Korean J Med. 2006;70(3):277-287.
- 원저 : 제2형 당뇨병 환자에서 비만과 경동맥 경화증과의 관계 (Original Articles : Association of carotid atherosclerosis and obesity in type 2 diabetic patients)
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강세훈, 김경민, 조동혁, 강호철, 정동진, 정민영
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Se Hoon Kang, Kyoung Min Kim, Dong Hyeok Cho, Ho Cheol Kang, Dong Jin Chung, Min Young Chung
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서울대학교 의과대학 내과학교실, 간연구소
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- Abstract
- Background : Diabetes mellitus is a major independent risk factor for atherosclerosis. In recent
years non-invasive high resolution B-mode ultrasound methods have been developed to measure the
intima-media thickness (IMT) of the carotid artery as an indicator for early atherosclerosis. It is
known that obesity plays a role in the development of type 2 diabetes and cardiovascular disease, and
it has also been reported that not only the amount but also the distribution of body fat is important.
This study investigated the relationship between obesity and the development of carotid
atherosclerosis in type 2 diabetic patients.
Methods
: Carotid IMT was measured by ultrasound B-mode imaging in 144 patients with type
2 diabetes mellitus. All subjects underwent assessment for the degree and distribution of obesity, the
presence of coronary artery disease risk factors, and the presence of diabetic complications.
Results
: Carotid IMT was increased in the abdominal obese group defined by waist
circumference. However, there was no significant difference in carotid IMT between the non-obese
group and obese group as defined by body mass index, waist to hip ratio, and total body fat percent
measured by bioelectrical impedance analysis. There were positive correlations between carotid IMT
and age, duration of diabetes, systolic blood pressure, and waist circumference. Multiple linear
regression analysis revealed the variable that interacted independently with carotid IMT was age in
type 2 diabetic patients. Carotid IMT was significantly increased in type 2 diabetic patients with
macrovascular complications and microvascular complications.
Conclusions
: This study suggested that abdominal obesity rather than general obesity was
associated with carotid atherosclerosis reflected by increment of carotid IMT in type 2 diabetic
subjects.(Korean J Med 70:277-287, 2006)
Key Words : Diabetes mellitus, Obesity, Atherosclerosis, Carotid artery
Keywords :Diabetes mellitus, Obesity, Atherosclerosis, Carotid artery
