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Original Article
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Korean J Med. 2006;70(2):207-212.
- 증례 : Docetaxel을 포함한 병합화학요법 후에 발생한 범발성 출혈성 대장염 1예 (Case Reports : A case of extensive hemorrhagic colitis after docetaxel - based combination chemotherapy)
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심현정, 조상희, 이준규, 안재숙, 양덕환, 김여경, 정익주
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Hyun Jeong Shim, Sang Hee Cho, Joon Kyoo Lee, Jae Sook Ahn, Deok Hwan Yang, Yeo Kyeoung Kim, Ik Joo Chung
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서울의대 내과
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- Abstract
- Gastrointestinal complications are frequently followed by combination chemotherapy. Based on
recent reports, colitis is very rare but serious complication associated with taxane based
chemotherapy. Despite of aggressive management, clinical course of colitis associated with
chemotherapy is potentially fatal. We report the first case in Korea who was developed extensive
colitis after docetaxel-based chemotherapy. A man aged 58 years with recurrent oral cavity
carcinoma received chemotherapy with docetaxel, cisplatin and 5-fluorouracil (5-FU). On the 7th day
of first cycle of chemotherapy, he complained of abdominal pain and fever, followed by hypotension
because of large amount of hematochezia. Abdominal CT and colonoloscopy revealed extensive
pancolitis with bleeding. He underwent two times of transarterial embolization with microcoils and
gelform. Nevertheless these managements, bleeding foci were remained. Then, colonoscopic
hemostasis such as hemoclipping and epinephrine injection were performed and fully recovered after
6 weeks.(Korean J Med 70:207-212, 2006)
Key Words : Colitis, Docetaxel, Chemotherapy
Keywords :Colitis, Docetaxel, Chemotherapy
