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Original Article
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Korean J Med. 2005;69(3):964-969.
- 증례 : D-Penicillamine에 의한 약물유발 폐렴 및 담즙 정체성 황달 1예
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류희정&#;안창혁&#;김선숙&#;백한주&#;박정웅&#;정성환&#;정동해, , , , , ,
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- A case of d-penicillamine-induced pneumonitis and cholestatic jaundice
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Hee Juang Ryu, Chang Hyeok An, Sun Suk Kim, Han Joo Baek, Jung Woong Park, Sung Hwan Jeong, Dong Hae Chung
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Department of Medicine, Sungkyunkwan University School of Medicine
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- Abstract
- It has been reported that D-penicillamine has pulmonary, renal, hepatobilliary and hematologic side effects. However, it is extremely rare that pulmonary infiltration occurs with cholestatic jaundice at the same time.
A 44-year-old woman with morphea developed fever and cough following a short exposure to D-penicillamine (10 days). Her sclera was slightly icteric and the liver function test was abnormal.
Bilateral diffuse ground glass appearance of lung was observed on HRCT. Liver biopsy revealed cholestasis with portal inflammation and hepatocytes injury. The patient regained a satisfactory recovery after cessation of D-penicillamine without steroid therapy. Simultaneous occurrence of drug-induced pneumonitis and cholestatic jaundice following even a short exposure to D-penicillamine should be recognized.(Korean J Med 69:S964-S969, 2005)
Keywords :Penicillamine, Adverse effect, Obstructive jaundice, Lung
