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Original Article
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Korean J Med. 2005;69(3):906-909.
- 증례 : Simvastatin 복용 중인 환자에서 Clopidogrel 병합요법 후 발생한 횡문근 융해증 1예
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권용수&#;김승태&#;송필상&#;류동열&#;최소연&#;이진영&#;김덕경, , , , , ,
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- A case of rabdomyolysis associated with simvastatin‐clopidogrel combination therapy
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Yong Soo Kwon, Seung Tai Kim, Pil Sang Song, Dong Ryeol Ryu, So Yeon Choi, Jin Young Lee, Duk-Kyung Kim
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Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea
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- Abstract
- Simvastatin, the 3‐hydroxy‐3methylglutaryl coenzyme (HMG‐CoA) reductase inhibitor is effective in reduction the risk of coronary event and are generally well tolerated. Rhabdomyolysis is uncommon complication of this drug. We describe a case of rhabdomyolysis associated with concomitant use of simvastatin and clopidogrel. Rhabdomyolysis occurred 30 days after clopidogrel added to a chronic stable dose of simvastatin, and resolved after discontinuation of simvastatin and clopidogrel. We recommend careful monitoring when clopidogrel is given to patients receiving simvastatin.(Korean J Med 69:S906-S909, 2005)
Keywords :Rhabdomyolysis, Clopidogrel, Simvastatin.
