| A 62-Year-Old Man with Weakness and Weight Loss for 3 Months |
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Sook Hyun Shin, Jeong-Ju Yoo, Sang Gyune Kim, Young Seok Kim |
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Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea |
| 3개월간 지속된 전신 피로감과 체중 감소를 주소로 내원한 62세 남자 |
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신숙현, 유정주, 김상균, 김영석 |
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순천향대학교 의과대학 순천향대학교 부천병원 소화기내과 |
Correspondence:
Jeong-Ju Yoo, Tel: +82-32-621-5215, Fax: +82-32-621-6079, Email: puby17@naver.com
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Received: 20 April 2026 • Revised: 30 June 2026 • Accepted: 21 July 2026 |
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| Abstract |
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Metabolic dysfunction-associated steatotic liver disease (MASLD) is emerging as a major cause of hepatocellular carcinoma (HCC) worldwide, driven by the increasing prevalence of obesity and metabolic disorders. The pathogenesis of MASLD-related HCC is multifactorial, involving insulin resistance, chronic inflammation, oxidative stress, genetic susceptibility, and alterations in the gut microbiome. While surveillance is well established for patients with cirrhosis, optimal strategies for non-cirrhotic MASLD remain unclear despite a substantial proportion of HCC arising in this population. Non-invasive tests, biomarkers, and novel approaches such as liquid biopsy may improve risk stratification and early detection. Further prospective studies are needed to establish effective, cost-efficient surveillance strategies. |
| Key Words:
Metabolic dysfunction-associated steatotic liver disease; Carcinoma, hepatocellular; Non-cirrhotic hepatocellular carcinoma; Risk assessment; Early detection of cancer |
| 주제어:
대사기능장애 관련 지방간질환; 간세포암; 비간경변 간암; 위험도 분류; 암 조기 진단 |
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