| Diagnosis of Antibiotic Resistance and Tailored Treatment Strategies for Helicobacter pylori Infection |
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Jin Hee Noh |
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Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea |
| 헬리코박터 파일로리 항생제 내성의 진단과 맞춤형 치료 전략 |
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노진희 |
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울산대학교 의과대학 서울아산병원 소화기내과 |
Correspondence:
Jin Hee Noh, Tel: +82-2-3010-3827, Fax: +82-2-3010-6517, Email: mdjh1432@gmail.com
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Received: 31 March 2026 • Revised: 13 April 2026 • Accepted: 22 April 2026 |
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| Abstract |
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Helicobacter pylori (H. pylori) infection is a major cause of various gastrointestinal diseases, including gastric cancer, underscoring the need for effective eradication therapy. However, the increasing prevalence of antibiotic resistance and emergence of multidrug-resistant strains have progressively reduced the efficacy of conventional empirical eradication regimens, posing a substantial clinical challenge. This review discusses the current status and major mechanisms of antibiotic resistance in H. pylori, summarizes the available diagnostic methods and their limitations, and reviews tailored treatment strategies, including susceptibility-guided therapy and antibiotic exposure history-based approaches. In addition, the roles of bismuth-containing regimens and potassium-competitive acid blockers in improving eradication efficacy are reviewed. Future management of H. pylori infections warrants a precision medicine approach that integrates regional resistance patterns and individual patient characteristics. The combined application of accurate diagnostic tools and optimized treatment strategies will help improve eradication outcomes. |
| Key Words:
Drug resistance, microbial; Helicobacter pylori; Precision medicine; Anti-bacterial agents |
| 주제어:
항생제 내성; 헬리코박터 파일로리; 정밀 의학; 항생제 |
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