| Patent Foramen Ovale Closure for Secondary Stroke Prevention |
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Hyue Mee Kim |
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Division of Cardiology, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea |
| 뇌경색 예방을 위한 난원공 경피적 폐쇄술 |
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김혜미 |
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중앙대학교 의과대학 중앙대학교병원 순환기내과 |
Correspondence:
Hyue Mee Kim, Tel: +82-3-6299-1417, Fax: +82-2-6263-2184, Email: hmkimmd@cau.ac.kr
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Received: 1 March 2025 • Revised: 16 September 2025 • Accepted: 23 September 2025 |
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| Abstract |
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Patent foramen ovale (PFO) is a common congenital cardiac anomaly that may serve as a conduit for paradoxical embolism, potentially leading to ischemic stroke. Randomized controlled trials have demonstrated that PFO closure effectively reduces stroke recurrence, with particularly favorable outcomes in patients with high-risk PFO features such as a large shunt size or atrial septal aneurysm. However, real-world clinical data have shown inconsistent findings, raising concerns regarding the generalizability of these results. Additionally, post-procedural atrial fibrillation remains a significant issue and requires careful patient selection. While recent studies have refined the criteria for identifying patients most likely to benefit from PFO closure, direct comparisons between PFO closure and non-vitamin K antagonist oral anticoagulants (NOACs) remain lacking. Further research is required to optimize long-term management strategies and evaluate treatment outcomes across diverse patient populations. |
| Key Words:
Foramen ovale, patent; Stroke; Embolism, paradoxical; Atrial fibrillation |
| 주제어:
난원공 개존증; 뇌경색; 역설적 색전증; 심방세동 |
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