| Molecular Methods for Tuberculosis Diagnosis and Drug Resistance Assessment |
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Kyung-Wook Jo |
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Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea |
| 분자 검사법을 통한 결핵의 진단과 내성 평가 |
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조경욱 |
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울산대학교 의과대학 서울아산병원 호흡기내과 |
Correspondence:
Kyung-Wook Jo, Tel: +82-2-3010-6809, Fax: +82-2-3010-6968, Email: heathcliff6800@hanmail.net
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Received: 18 April 2025 • Revised: 20 May 2025 • Accepted: 26 May 2025 |
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| Abstract |
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This article reviews the principles and clinical interpretation of molecular diagnostic tests for tuberculosis, focusing on Xpert MTB/RIF Ultra, line probe assays, whole genome sequencing, and targeted next-generation sequencing. These molecular tools provide rapid and accurate detection of Mycobacterium tuberculosis and its drug resistance profiles. Special attention is given to the discordance between genotypic and phenotypic drug susceptibility testing, including borderline resistance, heteroresistance, and rare genetic mutations. Understanding the strengths and limitations of each method is critical for accurate diagnosis, appropriate treatment selection, and improving patient outcomes. |
| Key Words:
Tuberculosis; Molecular diagnostic techniques; Drug resistance |
| 주제어:
결핵; 분자 검사법; 약제 내성 |
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