Brigandi et al. (2016) [10] |
GSK1278863 |
4 weeks |
Phase IIa |
Multicenter, randomized, single-blind, placebo-controlled, parallel-group study |
EPO, Ret, Hb, hepcidin |
NDD-CKD, DD-CKD |
Martin et al. (2017) [11] |
Vadadustat (AKBA6548) |
6 weeks |
Phase IIa |
Multicenter, randomized, doubl-blind, placebo-controlled, dose-ranging trial |
Hb, TIBC, ferritin, hepcidin |
NDD-CKD |
Akizawa et al. (2017) [12] |
Daprodustat (GSK1278863) |
4 weeks |
Phase II |
Multicenter, randomized, double-blind, placebo-controlled, dose-ranging, parallel-group study |
Hb, EPO, VEGF, ferritin, transferrin, TIBC, serum iron, hepcidin, TSAT |
DD-CKD |
Holdstock et al. (2016) [13] |
GSK1278863 |
4 weeks |
Phase IIa |
Multicenter, randomized, blinded, controlled, parallel-group studies |
Hb, EPO, hepcidin, ferritin, TSAT, transferrin, TIBC, serum iron, VEGF |
NDD-CKD, DD-CKD |
Chen et al. (2017) [14] |
FG-4592 |
12 weeks/7 weeks |
Phase II |
NDD study: randomized, double-blinded, placebo-controlled DD study: open-label, epoetin alfa-controlled |
Hb, RBC, Ret, hematocrit, MCV, PLT, CHr, leukocytes, TSAT, serum ironferritin, sTfR, hepcidin, total cholesterol, HDL, LDL, VLDL, triglycerides |
NDD-CKD, DD-CKD |
Besarab et al. (2015) [3] |
FG-4592 |
18 weeks |
Phase IIa |
Multicenter, randomized, single-blind subjects), placebo-controlled study |
Hb, EPO, TSAT, serum iron, TIBC, ferritin, hepcidin |
NDD-CKD |
Provenzano et al. (2016) [9] |
FG-4592 |
6-19 weeks |
Phase II |
Multicenter, randomized, open-label, consecutive cohort, multidose study |
Hb, EPO, ferritin, TSAT, serum iron, TIBC, sTfR, hepcidin, CHr, total cholesterol |
DD-CKD |
Pergola et al. (2016) [15] |
Vadadustat (AKB6548) |
20 weeks |
Phase Iib |
Randomized, double-blind, placebo-controlled study |
Urinary protein excretion rate, Hb, reticulocyte count, TIBC, TSAT, ferritin, hepcidin, VEGF |
NDD-CKD |
Ren (2013) |
FG-4592 |
8 weeks |
Undefined |
Randomized, double-blind, placebo-controlled clinical trial |
Hb, Hct, Ret, % Rtc, cholesterol, LDL-C, TSAT, serum iron, TIBC, transferrin, ferritin, sTfR |
NDD-CKD |