| Comparison of Guidelines for Management of Chronic Hepatitis C |
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Kyung-Ah Kim |
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Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea |
| 만성 C형 간염 진료 가이드라인 비교 |
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김경아 |
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인제대학교 의과대학 일산백병원 내과 |
Correspondence:
Kyung-Ah Kim, Tel: +82-31-910-7847, Fax: +82-31-910-7219, Email: kakim@ilsanpaik.ac.kr
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| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Abstract |
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Therapeutic options for patients with hepatitis C virus infection have evolved substantially with the advent of highly effective direct-acting antiviral agents (DAA). Guidelines for treatment of hepatitis C have changed with the evolution of hepatitis C treatments. However, it differs considerably among nations, as the approval and availability of new DAAs, cost-effectiveness, socioeconomic status, and timing of guideline revisions vary. Guidelines for management of hepatitis C by the Korean Association for the Study of the Liver, which was established in November 2013, recommend response-guided therapy with combination of peg-interferon-α and ribavirin (PR). Recommendations for testing, managing, and treating hepatitis C by the American Association for the Study of Liver Disease, which was established in January 2014 and keeps updated, recommend the combination therapy including new DAAs such as sofosbuvir, ledipasvir/sofosbuvir, simeprevir and ritonavir-boosted paritaprevir/ombitasvir/dasabuvir, and discourage use of PR with or without a first-generation protease inhibitor. The European Association of the Study of the Liver recommendations for treatment of hepatitis C revised in April 2015 suggest combination therapy, including new DAAs, such as sofosbuvir, ledipasvir/sofosbuvir, simeprevir, daclatasvir, and ritonavir-boosted paritaprevir/ombitasvir/dasabuvir. Guidelines for treating hepatitis C will be changing soon in Korea with the approval and release of new DAAs. |
| Key Words:
Guideline; Hepatitis C; Treatment; Direct-acting antivirals |
| 주제어:
가이드라인; C형 간염; 치료; 경구 항바이러스제 |
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