Multidrug-Resistant Gram-Positive Bacterial Infections

Jung, Younghee; Kim, Hong Bin

doi:2015.88.5.487

Korean J Med > Volume 88(5); 2015 > Article

Special Review

감염

The Korean Journal of Medicine 2015;88(5):487-501.
Published online May 1, 2015.
DOI: https://doi.org/10.3904/kjm.2015.88.5.487

Multidrug-Resistant Gram-Positive Bacterial Infections

Younghee Jung^1,2,3, Hong Bin Kim^1,2

¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
²Division of Infectious Diseases, Seoul National University Bundang Hospital, Seongnam, Korea
³Department of Internal Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea

다제내성 그람양성균 감염증

정영희^1,2,3, 김홍빈^1,2

^¹서울대학교 의과대학 내과학교실
^²분당서울대학교병원 감염내과
^³건양대학교 의과대학 건양대학교병원 내과

Correspondence:
Hong Bin Kim, Tel: +82-31-787-7021, Fax: +82-31-787-4052, Email: hbkimmd@snu.ac.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Antimicrobial resistance threatens the effective treatment of bacterial infections and is a serious problem worldwide. Multidrug-resistant bacteria are difficult to treat and the treatment outcome is worse than with susceptible bacteria. In Korea, the antibiotic resistance rates of the major Gram-positive bacteria methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococcus (VRE), and penicillin-resistant Streptococcus pneumoniae (PRSP) are very high. Clinicians should know the risk factors for developing multidrug-resistant bacterial infection, update the changing local epidemiology of resistant bacteria, and choose appropriate antibiotics in clinical practice. The overuse and misuse of broad spectrum antibiotics should be avoided. This review focuses on the epidemiology and risk factors of MRSA, VRE, and PRSP, the major multidrug-resistant Gram-positive bacteria.

Key Words: Methicillin-resistant Staphylococcus aureus; Vancomycin-resistant enterococcus; Penicillin-resistant Streptococcus pneumoniae

주제어: 메티실린 내성 황색포도알균; 반코마이신 내성 장알균; 페니실린 내성 폐렴사슬알균