Korean J Med > Volume 88(4); 2015 > Article
The Korean Journal of Medicine 2015;88(4):469-474.
Published online April 1, 2015.
DOI: https://doi.org/10.3904/kjm.2015.88.4.469   
A Case of Sequential Lymphoma in an Human Immunodeficiency Virus-Infected Patient
Yu Na Jung1, Jae Ryeong Lee1, Hee Sook Lee1, Bum Sik Jin1, Chang In Seo1, Hyoung-Shik Shin1, Eun Jung Jung2
1Departments of Internal Medicine, National Medical Center, Seoul, Korea
2Departments of Pathology, National Medical Center, Seoul, Korea
HIV 감염인에서 발생한 순차적 림프종 1예
정유나1, 이재령1, 이희숙1, 진범식1, 서창인1, 신형식1, 정은정2
1국립중앙의료원 내과
2국립중앙의료원 병리과
Correspondence: 
Hyoung-Shik Shin, Tel: +82-2-2262-4741, Fax: +82-2-2268-0803, Email: hyoungsshin@gmail.com
Received: 3 April 2013   • Revised: 30 May 2013   • Accepted: 4 July 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Rarely, two different histological types of lymphoma develop in the same person. Sequential lymphoma is defined as two different types of lymphoma occurring in the same person sequentially. A 47-year-old patient with human immunodeficiency virus (HIV) infection who had been diagnosed with mixed cellularity Hodgkin’s lymphoma was treated with adriamycin, bleomycin, vinblastine, and dacarbazine combination chemotherapy. After six cycles of chemotherapy, abdominal computed tomography showed multiple liver masses. A percutaneous needle biopsy of the liver and polymerase chain reaction single-strand conformation polymorphism revealed hepatosplenic T-cell lymphoma. The patient died 3 months after the diagnosis of hepatosplenic T-cell lymphoma. To our knowledge, this is the first case of the sequential development of hepatosplenic T-cell lymphoma after Hodgkin’s lymphoma in a Korean HIV-infected patient.
Key Words: Human immunodeficiency virus; Hodgkin’s lymphoma; T-cell lymphoma
주제어: 사람면역결핍바이러스; 호지킨 림프종; T-세포 림프종


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