| Chemotherapy in Elderly Patients with Colorectal Cancer |
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Hye Sook Han |
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Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea |
| 진행성 노인 대장암에 대한 항암요법 |
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한혜숙 |
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충북대학교 의과대학 내과학교실 |
Correspondence:
Hye Sook Han, Tel: +82-43-269-6260, Fax: +82-43-273-3252, Email: sook3529@hanmail.net
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| This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/bync/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Abstract |
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Colorectal cancer (CRC) affects largely elderly populations. However, older patients with CRC are generally excluded from randomized clinical trials, and the healthy subjects who are recruited are not representative of the general elderly patient population. Nevertheless, recent data from clinical trials specifically targeting elderly patients and related subgroup analyses indicate that well-selected elderly patients can have a similar response to that of younger patients. Chronological age should not determine the candidacy for adjuvant or palliative chemotherapy in elderly patients with CRC. The appropriate management of healthy elderly patients would mean that they could receive aggressive chemotherapy in a similar regimen to that of younger patients, whereas the care of frail elderly patients and those with a short life expectancy should focus on palliation. The use of a comprehensive geriatric assessment could allow the use of safe and beneficial chemotherapy regimens in elderly patients with CRC. |
| Key Words:
Chemotherapy; Colorectal cancer; Elderly |
| 주제어:
항암화학요법; 대장암; 노인 |
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