A Case of Etoposide Therapy in a Patient Newly Diagnosed with Classic Kaposi's
Sarcoma and Rheumatoid Arthritis

Choi, Nan Young; Park, Seung Ah; Han, Bo Ram; Kim, Ho Young; Min, Soo Kee; Kim, Hyo Jung; Zang, Dae Young

doi:2014.86.2.247

Korean J Med > Volume 86(2); 2014 > Article

Case Report

The Korean Journal of Medicine 2014;86(2):247-252.
Published online February 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.86.2.247

A Case of Etoposide Therapy in a Patient Newly Diagnosed with Classic Kaposi's Sarcoma and Rheumatoid Arthritis

Nan Young Choi¹, Seung Ah Park¹, Bo Ram Han¹, Ho Young Kim¹, Soo Kee Min², Hyo Jung Kim¹, Dae Young Zang¹

¹Departments of Internal Medicine, Hallym University College of Medicine, Anyang, Korea
²Departments of Pathology, Hallym University College of Medicine, Anyang, Korea

류마티스관절염이 동반된 고전형 카포시육종의 에토포사이드 치료 1예

최난영¹, 박승아¹, 한보람¹, 김호영¹, 민수기², 김효정¹, 장대영¹

^¹한림대학교 의과대학 내과학교실
^²한림대학교 의과대학 병리학교실

Correspondence:
Hyo Jung Kim, Tel: +82-31-380-3704, Fax: +82-31-386-2269, Email: hemonc@hallym.or.kr

Received: 27 April 2013 • Revised: 4 July 2013 • Accepted: 1 September 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Kaposi's sarcoma typically occurs in immunocompromised patients, especially those with acquired immunodeficiency syndrome. Human herpesvirus 8 (HHV-8) and human immunodeficiency virus (HIV) may play important roles in the development of Kaposi's sarcoma. We report the case of a 75-year-old male who presented with progressive multiple purplish papules and nodules on the skin for 3 months. Social and past medical histories seemed incompatible with an immunesuppressed condition and tests for HIV antibodies and HHV-8 were negative. He was newly diagnosed with rheumatoid arthritis, according to the 2010 ACR-EULAR criteria. Typical findings of Kaposi's sarcoma were confirmed by biopsy. After treatment with metronomic oral etoposide 25 mg once daily for 9 months, the skin lesions had almost resolved with no serious complication. Thus, we report a rare case of Kaposi’s sarcoma developing in a patient with newly diagnosed rheumatoid arthritis who showed a good response to oral etoposide. (Korean J Med 2014;86:247-252)

Key Words: HIV; Sarcoma, Kaposi; Herpesvirus 8, Human; Etoposide; Arthritis, Rheumatoid

주제어: 카포시육종; 사람면역결핍바이러스; 사람헤르 페스바이러스 8; 에토포사이드; 류마티스관절염