Acute Myeloid Leukemia with Persistent Marrow Aplasia after Chemotherapy
Treated with Reduced-Intensity Allogeneic Stem Cell Transplantation

Yoon, Hyunhwa; Hong, Junshik; Kim, Suyoung; Lee, Dongmin; Park, Jinny; Ahn, Jeong Yeal; Lee, Jae Hoon

doi:2014.86.2.242

Korean J Med > Volume 86(2); 2014 > Article

Case Report

The Korean Journal of Medicine 2014;86(2):242-246.
Published online February 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.86.2.242

Acute Myeloid Leukemia with Persistent Marrow Aplasia after Chemotherapy Treated with Reduced-Intensity Allogeneic Stem Cell Transplantation

Hyunhwa Yoon¹, Junshik Hong¹, Suyoung Kim¹, Dongmin Lee¹, Jinny Park¹, Jeong Yeal Ahn², Jae Hoon Lee¹

¹Departments of Internal Medicine, Gachon University School of Medicine, Incheon, Korea
²Departments of Laboratory Medicine, Gachon University School of Medicine, Incheon, Korea

동종이식으로 치료한 급성 골수성 백혈병 항암 치료 후 골수 무형성증 1예

윤현화¹, 홍준식¹, 김수영¹, 이동민¹, 박진희¹, 안정열², 이재훈¹

^¹가천대학교 의학전문대학원 내과
^²가천대학교 의학전문대학원 진단검사의학과

Correspondence:
Junshik Hong, Tel: +82-32-460-3229, Fax: +82-32-460-3233, Email: alertjun@hanmail.net

Received: 18 March 2013 • Revised: 2 May 2013 • Accepted: 12 August 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Persistent bone marrow aplasia after intensive chemotherapy is uncommon, but is one of the fatal complications in patients with acute myeloid leukemia (AML). Although allogeneic hematopoietic stem cell transplantation (HSCT) is considered to be contraindicated for patients who have hematologic diseases with serious infections, such as bacterial septicemia or invasive fungal diseases, combined with prolonged neutropenia due to frequent morbidity and mortality, such risks can be overcome by non-myeloablative conditioning and best supportive care. Here, we report an AML patient with persistent marrow aplasia after induction therapy, treated successfully with reduced-intensity allogeneic HSCT despite severe bacterial and fungal infections. (Korean J Med 2014;86:242-246)

Key Words: Acute myeloid leukemia; Stem cell transplantation; Aplastic anemia; Neutropenia; Chemotherapy

주제어: 급성 골수성 백혈병; 조혈모세포이식; 무형성 빈혈; 호중구 감소증; 항암화학요법