Korean J Med > Volume 78(4); 2010 > Article
The Korean Journal of Medicine 2010;78(4):507-511.
A case of nephrogenic systemic fibrosis following gadolinium exposure in a peritoneal dialysis patient
Tae Hyoung Koo, Dong Hyun Lee, Hee Kyung Baek, Do Kyong Kim, Bo Kyung Kim, Suk Hee Hong, Won Suk An
복막투석 환자에서 gadolinium 사용 후 발생한 콩팥성 전신성 섬유증 1예
구태형, 이동현, 백희경, 김도경, 김보경, 홍숙희, 안원석
Abstract
Nephrogenic systemic fibrosis is a systemic illness that only affects patients with kidney failure. Exposure to gadolinium-based contrast agents has been associated with the subsequent development of nephrogenic systemic fibrosis in patients with decreased renal function. Nephrogenic systemic fibrosis is characterized by skin induration after swelling and limited joint movement through a loss in flexibility that preferentially affects the extremities. A 58-year-old man in peritoneal dialysis developed swelling and stiffness of the lower limbs following gadolinium exposure for brain magnetic resonance imaging. This patient was diagnosed with nephrogenic systemic fibrosis by CD34 immunoreactivity of subcutaneous fibroblasts in a skin biopsy. We report, for the first time in Korea, that nephrogenic systemic fibrosis developed after gadolinium exposure in a peritoneal dialysis patient.
Key Words: Nephrogenic systemic fibrosis; Gadolinium; Peritoneal dialysis


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