| Recent advances in the treatment of adults with acute lymphoblastic leukemia |
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Seok Lee |
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1동아대학교 의과대학 내과학교실, 2부산의료원 신장내과 |
| 성인 급성림프구성백혈병 치료의 최신지견 |
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이석 |
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1Department of Internal Medicine, Dong-A University College of Medicine; 2Division of Nephrology, Busan Medical Center, Busan, Korea |
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| Abstract |
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Despite improvements in the achievement of complete remission and progress in the supportive care of adults with acute lymphoblastic
leukemia (ALL) during the last decade, the majority of patients have eventually relapsed with overall survival in adult
ALL of only 30~40%. However, recent therapeutic advances in allogeneic stem cell transplantation through the conduct of large
collaborative studies, better understanding of the relevance of cytogenetics and molecular determinants, improved molecular techniques
for the detection of minimal residual disease, and clinical research into novel biologic and targeted therapies have all combined
to offer potentially a better hope for an improved outcome in this uncommon and difficult disease. Full knowledge of the molecular
features associated with treatment response is required for precise leukemia prognostication and monitoring, and can provide
clues to useful targets for novel therapies. (Korean J Med 78:36-48, 2010) |
| Key Words:
Acute lymphoblastic leukemia; Adults; Prognostic factors; Postremission therapy |
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