| Validation of a modified ECRHS questionnaire for diagnosing asthma in patients with chronic cough |
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Ji Young Shin, Jeong Eun Lee, Ji Won Park, Sun Young Jung, Su Jin Yoo, Ji Hyun Yoon, Hee Sun Park, Sun Young Kim, Ju Ock Kim |
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| 만성 기침 환자에서 Modified ECRHS 설문을 이용한 천식진단의 유용성에 대한 연구 |
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신지영, 이정은, 박지원, 정선영, 유수진, 윤지현, 박희선, 김선영, 김주옥 |
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| Abstract |
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Background/Aims: Chronic cough may be the only manifestation of asthma. This study prospectively evaluated the validation of a modified European Community Respiratory Health Survey (ECRHS) questionnaire (including postnasal drip and GERD) in patients with chronic cough.
Methods: We recruited patients with a chronic cough exceeding 8 weeks from Oct. 2004 to March 2008. The patients had undergone an assessment using the modified ECRHS questionnaire, methacholine challenge test, chest PA, and PNS series, as well as the MAST and skin prick test in some patients.
Results: A total of 1518 patients were recruited. A total of 511 patients (33.6%) were physician diagnosed with asthma. Wheezing (53%, odds ratio [OR]: 2.989), nocturnal cough or dyspnea (57.3%,OR: 1.751), resting dyspnea (43.8%, OR: 2.216), post-exercise dyspnea (63.4%,OR: 2.297), esophageal reflux symptoms (34.1%, OR: 1.107) and postnasal drip (13.1%, OR: 1.116) are symptoms that have been reported. As the number of asthmatic symptoms included in the questionnaire increased, the number of patients diagnosed with asthma by a physician increased. The correlation between bronchial hyperresoponsiveness (BHR) and physician diagnosed asthma was evaluated by the area under the receiver operator characteristic (ROC) curve. The questionnaire was more correlated with BHR than with physician diagnosed asthma (area: 0.852 vs. 0.631).
Conclusions: The Modified ECRHS questionnaire is an available method to assist in the diagnosis of asthma and to evaluate BHR in patients with chronic cough.
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| Key Words:
Chronic cough; Modified ECRHS questionnaire; Asthma |
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