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Novel molecular-targeted therapies involving various kinds of kinase inhibitors show promising results in the treatment of advanced thyroid carcinoma refractory to conventional treatment such as surgery and radioiodine treatment. Partial response rates around 15~30% and disease stabilization in additional 30~60% are reported in clinical trials using these drugs. In this review, the introduction about many kinase inhibitors in clinical trials nowadays and the results focusing on phase 2 trial will be discussed. With the development of this various kinds of potent kinase inhibitors and encouragement of enrollment to further clinical trials will give hope to the patients with refractory thyroid cancer in the near future. |
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