| Acute generalized exanthematous pustulosis due to amoxicillin/clavulanate |
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Song Mi Moon, Mi Suk Lee, Jun Seong Son |
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| 인후염 치료 중 발생한 급성 전신발진농포증 1예 |
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문송미, 이미숙ㆍ손준성, Jun Seong Son |
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| Abstract |
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Acute generalized exanthematous pustulosis (AGEP) was initially named by Beylot to describe a disease entity with sudden-
onset amicrobial pustular eruptions accompanied by fever and leukocytosis. Most cases appear to be related to drug reactions,
mainly antibiotics, although viral infections and hypersensitivity to mercury also cause AGEP. A 28-year-old woman presented
with sudden-onset, multiple, and generally pinhead-sized pustules on an erythematous base scattered on the face and anterior chest
wall. The patient had been on amoxicillin/clavulanate for acute pharyngitis. Histopathologically, the skin biopsy specimen revealed
subcorneal and subepidermal pustules with neutrophil spongiosis, perivascular neutrophilic infiltration, and karyorrhectic debris.
The eruption cleared rapidly after discontinuing the drug and administering systemic corticosteroid therapy. (Korean J Med
76:S216-S219, 2009) |
| Key Words:
Acute generalized exanthematous pustulosis; Pustular drug rash; Amoxicillin/clavulanate |
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