| Genetic studies of allergic disease and their clinical implications |
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Seung-Hyun Kim, Hae-Sim Park |
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| 알레르기 질환에서 유전체 연구 현황과 임상적 유용성 |
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김승현, 박해심 |
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| Abstract |
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Allergic disease is a complex disorder in which the interaction between environmental and genetic effects may modify both the
susceptibility to and severity of the disease. Over the last few years, our understanding of the genetic basis of allergic diseases has
improved markedly, which has led to the identification of several chromosome regions and loci showing linkage to allergic disease.
As another approach, association studies between candidate gene polymorphisms and allergic diseases have been conducted in
many areas and replicated in different ethnic groups. These approaches need to be followed by validation processes to confirm their
functional relevance in the pathophysiology of allergic disease. This review updates genetic studies of and recent findings in, allergic
disease. (Korean J Med 76:416-424, 2009) |
| Key Words:
Allergic disease; Genetic study; Positional cloning; Association study |
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