| A case of rifampicin-induced interstitial pneumonitis |
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Jeong Ihm Jeong, Bock Hyun Jung, Mi Hye Kim, Yong Jin Park, Tae Yun Hea, Dae Sik Rhui, Gil Hyun Kang |
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경희대학교 의과대학 순환기내과학교실 |
| 증례: Rifampicin에 의해 유발된 간질성 폐렴 1예 |
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정정임.정복현.김미혜.박용진.허태윤.류대식.강길현, Bock Hyun Jung, Mi Hye Kim, Yong Jin Park, Tae Yun Hea, Dae Sik Rhui, Gil Hyun Kang |
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| Abstract |
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Rifampicin is a powerful agent for the treatment of pulmonary tuberculosis. However, it may induce several adverse effects, including rare cases of lung toxicity. Here, we report a case of rifampicin-induced interstitial pneumonitis. A 57-year-old woman diagnosed with cerebellar tuberculoma developed progressive dyspnea after the 5th day of anti-tuberculosis medication. Chest X-ray revealed newly developed ground glass opacities on both lower lung fields. Drug-induced pneumonitis was suspected and all anti-tuberculosis medications were halted. Transbronchial lung biopsy was consistent with desquamative interstitial pneumonitis. After clinical improvement, a rechallenge test with each anti-tuberculosis medication was attempted. No primary anti-tuberculosis drug except rifampicin triggered recurrence of symptoms, supporting a diagnosis of rifampicin-induced interstitial pneumonitis. Clinicians should be aware of this rare, but serious, side effect of rifampicin treatment. (Korean J Med 75:592-596, 2008) |
| Key Words:
Drug-induced pneumonitis; Rifampicin; Tuberculosis |
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