| Genetic susceptibility factors of rheumatoid arthritis |
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Hye-Soon Lee |
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1Department of Cardiology, Catholic University of Daegu College of Medicine, Daegu, Korea |
| 종설: 류마티스관절염의 유전적 요인 |
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이 혜 순 |
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| Abstract |
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Rheumatoid arthritis (RA) is a chronic autoimmune disease that mainly involves the joints. Although the full etiology remains unclear, both genetic and environmental factors contribute to disease. Recently, genetic studies of RA, which include whole-genome linkage study, candidate gene association study, and especially genome-wide association study, made much progress through the advances in technology and large collection of case-controls. These various approaches provided new susceptible genes such as PTPN22, PADI4, STAT4, TNFAIP3, TRAF1-C5, CD40 gene in addition to HLA-DRB1. This review will cover an update in recent progress in RA genetics, focusing mainly on the several novel loci. (Korean J Med 75:515-524, 2008) |
| Key Words:
Rheumatoid arthritis; Gene, Genome-wide association study |
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