Utility of CT colonography in detecting colon polyps as a colon cancer screen

Yun Jung Park,; Seung Eun Jung,; Shin Ae Park,; Jee Hee Kim,; Eun Hee Chang,; Myoung Beom Koh,; Dae Young Cheung,; Jin Il Kim,; Se Hyun Cho,; Soo-Heon Park,; Joon-Yeol Han,; Jae Kwang Kim,

Korean J Med > Volume 75(4); 2008 > Article

Original Article

The Korean Journal of Medicine 2008;75(4):420-427.

Utility of CT colonography in detecting colon polyps as a colon cancer screen

Yun Jung Park, Seung Eun Jung, Shin Ae Park, Jee Hee Kim, Eun Hee Chang, Myoung Beom Koh, Dae Young Cheung, Jin Il Kim, Se Hyun Cho, Soo-Heon Park, Joon-Yeol Han, Jae Kwang Kim

한양대학교 의과대학 호흡기내과

원저: 대장암 선별검사로서 대장 용종 발견에 대한 CT 대장조영술의 유용성

박윤정.정승은.박신애.김지희.장은희.고명범.정대영.김진일.조세현.박수헌.한준열.김재광, Seung Eun Jung, Shin Ae Park, Jee Hee Kim, Eun Hee Chang, Myoung Beom Koh, Dae Young Cheung, Jin Il Kim, Se Hyun Cho, Soo-Heon Park, Joon-Yeol Han, Jae Kwang Kim

Abstract

Background/Aims: CT colonography is a rapid and safe imaging method for detecting polyps in the colon and rectum. We assessed the efficacy of CT colonography in colorectal polyp detection. Methods: We prospectively studied 84 subjects (mean age 55.7¡¾11.1 years; 52 men, 32 women) undergoing CT colonography followed by colonoscopy. Based on the results of CT colonography, all polyps were classified by size (any size, and those larger than 5, 7, and 10 mm) and were checked for location, morphology, and histological characteristics. We determined the sensitivity and specificity of CT colonography using colonoscopy as a reference standard with a segmental unblinding method. Results: A total of 56 lesions were identified in 26 of 79 subjects undergoing both CT colonography and conventional colonoscopy. The sensitivities of CT colonography for polyps of any size, and larger than 5, 7, and 10 mm were 60.7%, 70.5%, 75.9%, and 81.8%, respectively. The per-subject sensitivities of CT colonography for the polyps of any size, and larger than 5, 7, and 10 mm, were 80.7%, 95.0%, 93.3%, and 90.9%, respectively. The per-subject specificities of CT colonography for polyps were 86.8%, 89.8%, 95.3%, and 100.0%, respectively. The sensitivities of CT colonography for flat, sessile, and pedunculated polyps were 30.8%, 85.0%, and 90.0%, respectively. Conclusions: CT colonography is a useful diagnostic method for screening colorectal neoplasias larger than 7 mm diameter, showing 75.9% sensitivity and 71.0% positive predictive value. (Korean J Med 75:420-427, 2008)

Key Words: Colon polyp; CT colonography; Colonoscopy.