| Non-invasive Doppler ultrasonography for assessment of the portal hypertension of liver cirrhosis: A prospective study |
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Kyu Hong Kim, Moon Young Kim, Soon Koo Baik, Dong Hun Park, Dae Wook Rhim, Jung Min Kim, Ki Tae Suk, Jae Woo Kim, Sang Ok Kwon |
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서울대학교 의과대학 내과학교실1, 경희대학교 의과대학 내과학교실2 |
| 원저 : 문맥압 항진증 평가에 유용한 도플러 초음파 검사법 |
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김규홍 . 김문영 . 백순구 . 박동훈 . 임대욱 . 김정민 . 석기태 . 김재우 . 권상, Moon Young Kim, Soon Koo Baik, Dong Hun Park, Dae Wook Rhim, Jung Min Kim, Ki Tae Suk, Jae Woo Kim, Sang Ok Kwon |
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| Abstract |
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Background/Aims : Portal hypertension occurs as a consequence of liver cirrhosis and is responsible for serious complications such as variceal bleeding, ascites and hepatic encephalopathy. The hepatic venous pressure gradient (HVPG) is the gold standard for assessment of portal hypertension. However, use of the HVPG is limited by being an invasive test. This prospective study evaluated whether the parameters identified by the non-invasive Doppler ultrasonography reflect the HVPG and could potentially be used for the assessment of the severity of portal hypertension in patients with liver cirrhosis.
Methods : HVPG and Doppler ultrasonographic parameters, including the damping index (DI) of the hepatic vein waveform, the portal venous velocity and flow, the splenic venous velocity and flow, the pulsatility and the resistive index of the hepatic, splenic and renal arteries were measured in 114 patients with liver cirrhosis and compared.
Results : The DI of the Doppler hepatic vein waveform was significantly correlated with the grade of the HVPG, i.e. with a higher HVPG, an increase in the DI was observed (p<0.01). The other Doppler parameters did not correlate with the HVPG grade.
Conclusions : The results of this study showed that the DI measurements of the hepatic vein waveform by Doppler ultrasonography might provide a noninvasive assessment of the severity of portal hypertension.
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| Key Words:
Doppler ultrasonography; Hepatic venous pressure gradient; Portal hypertension; Liver cirrhosis |
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