| Correlation between inflammatory markers and the progression of atherosclerosis in patients with coronary artery disease |
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Jun Ho Bae, Jong Seon Park, Geu Ru Hong, Dong Gu Shin, Young Jo Kim, Bong Sup Shim |
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Cardiology Division, Department of Internal Medicine, Yeungnam University Hospital1 |
| 원저 : 관상동맥질환자에서 동맥경화증의 진행과 염증 표지자의 상관관계 |
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배준호 . 박종선 . 홍그루 . 신동구 . 김영조 . 심봉섭, Jong Seon Park, Geu Ru Hong, Dong Gu Shin, Young Jo Kim, Bong Sup Shim |
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| Abstract |
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Background/Aims : Inflammation plays a key role in the pathogenesis and progression of cardiovascular disease (CAD). A small number of recent studies reported anti‐inflammatory therapy achieved a reduction of CAD progression. The aim of the present study was to explore the roles of inflammatory markers and the conventional risk factors for CAD progression.
Methods : One hundred and fifty patients (58¡¾10 years, 112 men) who underwent percutaneous coronary intervention and follow-up angiography (mean duration, 7.5¡¾2.0 months) were enrolled in this study. On comparison of the coronary angiographic findings, the patients were divided into the progression and non‐progression groups. The serologic inflammatory markers were angiography measured at the time of follow up. The clinical characteristic and inflammatory markers were compared between the two groups and the independent predictors of CAD progression were analyzed. CAD progression was defined as more than 30% diameter reduction of a pre‐existing luminal stenosis.
Results : CAD progression occurred in 32 patients (21.3%). The frequency of diabetes mellitus (37.5% versus 19.5%, respectively, p=0.033) and the number of the disease vessels (p=0.003) were higher in the CAD progression group. In terms of the inflammatory markers, the progression patients had higher hsCRP (p=0.023), MCP-1 (p=0.036), sVCAM-1 (p=0.000), sP-selectin (p=0.000) and sCD40L (p=0.001) levels. Multiple logistic regression analysis of the variables showed that the logCRP (relative risk (RR) 5.016, CI=1.384-18.177, p=0.014) logVCAM-1 (RR 11.854, CI=1.883-74.614, p=0.008) and triple vessel disease of the coronary arteries (RR 5.037, CI=1.550-16.350, p=0.007) were independent predictors of CAD progression.
Conclusion : In the present study, the extent of coronary artery disease and inflammatory markers like hsCRP and VCAM-1 were independent predictors for the progression of atherosclerotic lesions. (Korean J Med 74:51-58, 2008)
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| Key Words:
Cell adhesion molecules; Inflammation; Coronary disease |
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