A case of severe hepatitis caused by dapsone syndrome successfully treated with steroids

Chang Hoon Lim,; Si Hyun Bae,; .,; Jeong Ah Shin,; Jae Sun Uhm,; Chan Ran You,; Jong Young Choi,; .,; Seung Kew Yoon,; . ,

Korean J Med > Volume 73(3); 2007 > Article

Original Article

The Korean Journal of Medicine 2007;73(3):915-919.

A case of severe hepatitis caused by dapsone syndrome successfully treated with steroids

Chang Hoon Lim, Si Hyun Bae, ., Jeong Ah Shin, Jae Sun Uhm, Chan Ran You, Jong Young Choi, ., Seung Kew Yoon, .

성균관대학교 의과대학 삼성서울병원 심장혈관센터 순환기내과

증례 : Dapsone 증후군에 의한 중증 간염을 스테로이드로 치료한 1예

임창훈&#;배시현, &#;신정아&#;엄재선&#;유찬란&#;최종영, &#;윤승규, Jeong Ah Shin, Jae Sun Uhm, Chan Ran You, Jong Young Choi, ., Seung Kew Yoon, .

Abstract

Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by a high fever, papular or exfoliative dermatitis, hemolytic anemia, liver toxicity and generalized lymphadenopathy. It is difficult to differentiate dapsone syndrome from any other viral rash, such as infectious mononucleosis. We report a case of a 59-year-old woman who presented with severe hepatitis after receiving 100 mg of dapsone once daily for 6 weeks due to suspicious Behcet's disease. Fever, severe hepatitis, mobiliform rashes on her entire body, hemolytic anemia and acute renal failure developed. The patient recovered successfully without any serious complications following the discontinuation of dapsone and the administration of steroids (0.5 mg/kg).(Korean J Med 73:S915-S919, 2007)

Key Words: Dapsone syndrome, Severe hepatitis, Hypersensitivity syndrome, Hemolytic anemia.