| A case of primary hepatocellular carcinoma that presented with dysarthria |
|
So Young Park, Hea Won Park, Jung A Lee, Ji Won Park, Sung Jun Kim, Hyun Kyu Kim, Myoung Kuk Jang |
|
경희대학교 의과대학 순환기내과학교실 |
| 증례 : 구음 장애로 발현된 원발성 간세포암 1예 |
|
박소영&#;박혜원&#;이정아&#;박지원&#;김성준&#;김현규&#;장명국, Hea Won Park, Jung A Lee, Ji Won Park, Sung Jun Kim, Hyun Kyu Kim, Myoung Kuk Jang |
|
|
|
|
|
|
| Abstract |
|
Paraneoplastic syndrome is not uncommon in primary hepatocellular carcinoma (HCC), and this syndrome includes
hypercholesterolemia, hypoglycemia, hypercalcemia, erythrocytosis and polycythemia. Of them, dysarthria may be a
neurologic manifestation associated with hypercalcemia. A 48-year-old man visited to our neurosurgery department
because of dysarthria. On the past medical history, he was found to be hepatitis B surface antigen positive 10 years ago.
There were no neurologic abnormalities associated with his dysarthria. The laboratory findings showed elevated serum
calcium levels at 14.8 mg/dL (normal range: 8.4-10.2 mg/dL), but the parathyroid hormone (PTH) levels were decreased
to 0.1 pg/mL (normal range: 10-57 pg/mL). Interestingly, PTH-related peptide (PTH-rp) was increased to 3.5 pg/mL
(normal range: <1.3 pg/mL), and PTH-rp might be released from malignancies. Dynamic CT demonstrated a
hypervascular mass 10 cm in diameter with underlying cirrhotic change, and this was suggestive of HCC. We report here
on a case of HBV-associated HCC that presented with dysarthria associated with humoral hypercalcemia according to
the elevated PTH-rp.(Korean J Med 73:S905-S909, 2007) |
| Key Words:
Hepatocellular carcinoma, Paraneoplastic syndrome, Dysarthria |
|
PDF Links
Full text via DOI
Download Citation
