| A case of acute interstitial nephropathy and toxic hepatitis after short-term herbal medication |
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Won Yik Lee, Byeong Chool Park, Hee-Sung Kim, Ki Ok Joung, Su In Yoon, Soon Kil Kwon, Hye-Young Kim |
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이화여자대학교 의과대학 내과학교실 |
| 증례 : 단기간의 한약 복용후 독성 간염과 함께 발생한 급성 간질성 신염 1예 |
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이원익, 박병출, 김희성, 정기옥, 윤수인, 권순길, 김혜영 |
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Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea |
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| Abstract |
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There are many kinds of herbal medication available in Korea, and some of them have been reported to be related
with renal failure. However, the simultaneous occurrence of toxic hepatitis and acute renal failure associated with herbal
medicine has rarely been reported. A 26-year-old male was admitted with a sudden onset of jaundice and generalized
weakness after taking two doses of herbal medication. A physical examination revealed no abnormalities other than
scleral icterus. The patient's blood chemistry demonstrated a blood urea nitrogen level of 91 mg/dL, a creatinine level
of 13 mg/dL, an AST of 212 IU/L, an ALT of 1,528 IU/L and a bilirubin level of 8.5 mg/dL. Renal biopsy showed
interstitial edema and an infiltration of neutrophils and lymphocytes with preserved glomeruli and vascular structure;
these findings were consistent with administering medical supportive care without renal replacement therapy. He was
discharged on the 8th hospital day. This case provides the possibility of development of hepatitis and renal failure due
to herbal medication. We propose that a meticulous history taking for determining the herbal medications a patient has
taken should be done for those cases of simultaneous toxic hepatitis and renal failure that are without any obvious cause
in Korea.(Korean J Med 73:103-106, 2007)
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| Key Words:
Drugs, Chinese Herbal, Kidney Failure, Acute, Hepatitis |
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