| The histological features of papillary thyroid carcinomas 1.5 cm and less in size |
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Sun-Hye Shin, Min-Ah Na, Yang-Ho Kang, Seok-Man Son, In-Ju Kim, Yong-Ki Kim |
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경상대학교 의과대학 내과학교실 |
| 원저 : 크기 1.5 cm 이하의 작은 갑상선 유두암의 예후를 고려한 조직학적 고찰 |
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신선혜, 나민아, 강양호, 손석만, 김인주, 김용기 |
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Department of Internal Medicine, Gyeong-Sang National University College of Medicine, Jinju, Korea |
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| Abstract |
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Background : A number of studies have shown that papillary microcarcinomas have a more favorable prognosis than
do the larger tumors. However, some microcarcinomas may have a negative outcome. So, we investigated the histological
features of small (≤1.5 cm) papillary thyroid carcinomas, and we compared them with the larger (>1.5 cm) tumors.
Methods : Between January, 1996 and December, 2000, 178 patients were diagnosed and operated on for their
differentiated papillary thyroid carcinoma at Pusan National University Hospital. We reviewed the charts and pathologic
records of these patients and we analyzed them retrospectively. According to the tumor size 1.5cm, we divided the
tumors into two groups and then compared the histological features.
Results : Small papillary thyroid carcinomas have a favorable outcome in most cases. However, small papillary
thyroid carcinomas present with signs of aggressiveness at presentation, including lymph node metastases (33.3%),
multifocality (12.5%), bilateral involvement (12.5%) and extrathyroidal extension (16.7%). Compared with larger tumors,
the frequency of theses signs was similar, except for lymph node metastases, in the small papillary thyroid carcinomas.
Conclusions : Approximately one third of the small papillary thyroid cancer 1.5 cm and less in size had neck lymph
node metastases at presentation and the signs of aggressiveness were similarly present as compared with the larger
tumors. We suggested that the standard treatment is desirable as a therapeutic strategy of small papillary thyroid
carcinoma.(Korean J Med 73:44-49, 2007)
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| Key Words:
Papillary thyroid carcinoma, Papillary microcarcinoma, Histological feature |
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