| Abnormalities of liver function tests in patients with hyperthyroidism |
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Kyung Hoon Chae, Dae Soon Kwon, Kwan Woo Nam, Sun Hyung Kang, Jeong Il Kim, Won Seok Heo, Jae Hoon Jung, Hyun Mo Kang, Yoon Sae Kang, Yeon Soo Kim, Seok Hyun Kim, Jae Kyu Seong, Byung, |
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중앙대학교 의과대학 내과학교실 |
| 원저 : 갑상선 기능항진증 환자에서 나타난 간기능검사의 이상소견 |
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채경훈, 권대순, 남관우, 강선형, 김정일, 허원석, 정재훈, 강현모, 강윤세, 김연수, 김석현, 성재규, 이병석, 이헌영 |
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Department of Internal Medicine, College of Medicine, Chungang University, Seoul, Korea |
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| Abstract |
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Background : Abnormalities of liver function tests are common in patients with hyperthyroidism and may reflect
thyroid hormone status. The aim of our study was to analyze the frequency of abnormal liver function tests in the
patients with hyperthyroidism at diagnosis and the association with the thyroid function state after antithyroid therapy.
Methods : Three hundred seventy eight patients with hyperthyroidism who visited Chungnam National University
Hospital from June 2004 to May 2005 and had no other causes for abnormal liver function tests were examined. At
diagnosis, 272 of 378 patients had various abnormalities seen on the liver function tests. Among 272 patients, 65 were
followed up for liver function tests and were analyzed for sex, age, use of an antithyroid drug, and thyroid function tests
after administration of an antithyroid drug. We analyzed the frequency of liver function abnormalities and the relevance
between abnormalities of liver function and the thyroid function state.
Results : Abnormalities in AST, ALT, total bilirubin, alkaline phosphatase and GGT were observed in 16.4%, 31.0%,
3.2%, 48.7% and 26.9% of the 378 patients with hyperthyroidism, respectively. The level of alkaline phosphatase was the
most common abnormal parameter. After antithyroid therapy, 48 (73.8%) of 65 patients had normalization of their liver
function abnormalities. The normalization rate for AST, ALT, alkaline phosphatase and GGT were higher in the
euthyroid status group than the sustained hyperthyoid status group. The normalization rate for ALT was significantly
higher in the female group than in the male group, but the effect of antithyroid drug use and age on the normalization
rate was not statistically significant.
Conclusions : These findings indicate that abnormalities of liver function tests are common in patients with
hyperthyroidism and these abnormalities are strongly associated with thyroid hormone status.(Korean J Med 73:18-24,
2007)
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| Key Words:
Hyperthyroidism, Abnormal liver function tests |
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